Introduction: Various biomarkers are studied as a prognostic factor in ischemic stroke, the results obtained about uric acid are controversial. Objective: To determine if there is a relationship between uricemia and the neurological functional state in acute ischemic stroke. Material and methods: A study was carried out that included 151 patients diagnosed with acute isquemic stroke from the neurology department of the Victor Lazarte Echegaray Hospital and Alta Complejidad Virgen de la Puerta Hospital that met the selection criteria, the relationship between uricemia and neurological functional prognosis using the modified Rankin Scale (mRS), using the Eta statics. Results: 55.6% of the patients had a poor neurological functional prognosis (mRS>2) reporting acid uric levels with a mean of 4.13 mg/dl. An Eta coefficient of 0.940 was obtained. Conclusion: There is a direct relationship between uricemia and neurological functional state in patients with acute ischemic stroke, associating more extreme values with the worst functional prognosis at hospital discharge.