Title
Intravitreal bevacizumab for inflammatory choroidal neovascularization: Results from the Pan-American collaborative retina study group at 24 months
Date Issued
01 February 2011
Access level
open access
Resource Type
journal article
Author(s)
Arevalo J.F.
Adan A.
Berrocal M.H.
Espinoza J.V.
Maia M.
Wu L.
Quiroz-Mercado H.
Ruiz-Moreno J.M.
Serrano M.A.
Abstract
Background: To evaluate the anatomical and functional outcomes of intravitreal bevacizumab (1.25 or 2.5 mg) in the treatment of inflammatory choroidal neovascularization at 24 months. Methods: We reviewed the clinical records of 22 consecutive patients (23 eyes) with choroidal neovascularization secondary to chorioretinal inflammatory disease in this interventional retrospective multicenter case series. Sixteen eyes (63.6%) received a dose of 1.25 mg of intravitreal bevacizumab, and 7 eyes (36.4%) received a dose of 2.5 mg of intravitreal bevacizumab. Results: At baseline, the mean best-corrected visual acuity was 0.68 logarithm of minimum angle of resolution (Early Treatment Diabetic Retinopathy Study chart = 20/100). After intravitreal bevacizumab, best-corrected visual acuity improved significantly to 0.41 logarithm of minimum angle of resolution (20/51), 0.42 logarithm of minimum angle of resolution (20/53), and 0.40 logarithm of minimum angle of resolution (20/50) at 6, 12, and 24 months, respectively (P < 0.05). Fourteen eyes (60.8%) received 1 injection. Central macular thickness by optical coherence tomography decreased from 375.3 μm (range: 240-634 μm) at baseline to 241.6 μm (range: 189-306 μm) at 24 months of follow-up (P < 0.0001). Conclusion: Intravitreal bevacizumab at doses of 1.25 mg and 2.5 mg seems to provide stability or improvement in best-corrected visual acuity, optical coherence tomography, and fluorescein angiogram in inflammatory choroidal neovascularization at 24 months. All patients were treated after the underlying uveitic condition was controlled. © The Ophthalmic Communications Society, Inc.
Start page
353
End page
363
Volume
31
Issue
2
Language
English
OCDE Knowledge area
Oftalmología Farmacología, Farmacia
Scopus EID
2-s2.0-79551508522
PubMed ID
Source
Retina
ISSN of the container
0275004X
Sources of information: Directorio de Producción Científica Scopus