Prionace glauca is a top predator, prone to bioaccumulate trace elements, representing the most captured elasmobranch species for human consumption in Peru. Concentrations of cadmium and lead in the edible muscle tissue of the blue shark captured in the south Peruvian coastal waters and offshore north-central Chile were determined. The Cd and Pb levels varied between 0.004 and 0.014 and 0.004 and 0.03 mg kg−1, respectively. We found direct correlation of Cd concentration with the total length, nevertheless there was no clear relationship regarding sex, seasons, and capture areas. Both metals were below the safety limits for human consumption. The target hazard quotient (THQ) values suggest that its consumption does not represent a risk to the human health. In Peru, this is only the second paper that reports Cd and Pb in sharks. We recommend increasing the sampling by including larger sharks and in other regions of the Peruvian coastline.