In this paper, we attempted to design and assess a sustainable networked delivery (SND) system, which can achieve significant reductions of energy consumption and environmental emissions of critical local pollutants and greenhouse gases due to growing local transportation in urban areas. SND system is a combination of e-commerce and centralized pickup point (PP), with the PP being a location that the consumer will already be visiting regularly. Transportation energy consumption and concomitant emissions in the three delivery systems (traditional networked delivery (TND) system, e-commerce networked delivery (END) system, and sustainable networked delivery (SND)) were compared. Our research results show that the SND system has a lot of possibilities to save local transportation energy consumption and reduce environmental emissions in delivery system.