Hybrid materials constituted by hydroxyapatite (HAp) and both biodegradable and natural polymers have a great interest that mainly covers the biomedical field in applications relative to tissue-engineering and even drug delivery systems. On the other hand, polylactide (PLA) is one of the most employed biodegradable polymers due to its good properties, the capability to be synthesized from renewable resources, and even the possibility to tune some properties through the change in its stereoisomeric composition. The present review concerns to the specific developments that recently have been carried out with PLA/HAp composites. These include, for example, their use as representative systems of bone repairing with good biocompatibility and the research on carrier systems that release osteogenic drugs for orthopedic treatments.