cris.boxmetadata.label.title
Cancer Cells Microsurgery via Asymmetric Bent Surface Au/Ag/Ni Microrobotic Scalpels through a Transversal Rotating Magnetic Field
cris.boxmetadata.label.dateissued
28 browse.startsWith.months.july 2020
cris.boxmetadata.label.accesslevel
metadata only access
cris.boxmetadata.label.resourcetype
journal article
cris.boxmetadata.label.authors
Vyskočil J.
Jablonská E.
Novotný F.
Ruml T.
Pumera M.
University of Chemistry and Technology
cris.boxmetadata.label.publisher
American Chemical Society
cris.boxmetadata.label.abstract
The actuation of micro/nanomachines by means of a magnetic field is a promising fuel-free way to transport cargo in microscale dimensions. This type of movement has been extensively studied for a variety of micro/nanomachine designs, and a special magnetic field configuration results in a near-surface walking. We developed "walking"micromachines which transversally move in a magnetic field, and we used them as microrobotic scalpels to enter and exit an individual cancer cell and cut a small cellular fragment. In these microscalpels, the center of mass lies approximately in the middle of their length. The microrobotic scalpels show good propulsion efficiency and high step-out frequencies of the magnetic field. Au/Ag/Ni microrobotic scalpels controlled by a transversal rotating magnetic field can enter the cytoplasm of cancer cells and also are able to remove a piece of the cytosol while leaving the cytoplasmic membrane intact in a microsurgery-like manner. We believe that this concept can be further developed for potential biological or medical applications.
cris.boxmetadata.label.citationstartpage
8247
cris.boxmetadata.label.citationendpage
8256
cris.boxmetadata.label.volume
14
cris.boxmetadata.label.issue
7
cris.boxmetadata.label.language
English
cris.boxmetadata.label.ocdeknowledgeArea
Oncología Bioquímica, Biología molecular
cris.boxmetadata.label.doi
cris.boxmetadata.label.scopusidentifier
2-s2.0-85087004011
cris.boxmetadata.label.pubmedidentifier
cris.boxmetadata.label.source
ACS Nano
cris.boxmetadata.label.containerissn
19360851
cris.boxmetadata.label.sponsor
This work was supported by the project Advanced Functional Nanorobots (reg. no. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR).
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