Objective: To determine whether concern due to COVID-19, social support, and anxiety are predictors of depression in Peruvian nurses during a health emergency. Material and Methods: Cross-sectional predictive study, conducted on 216 Peruvian nur-ses, to whom the Social Support at Work Scale (EAST), the Concern for COVID-19 Scale (EPPC-Cov19), the Generalized Anxiety Disorder Scale-2 (GAD-2) and the Patient Health Question-narie-2 (PHQ-2) were applied. Data were analyzed using correlation coefficients and multiple linear regression models. Results: Significant correlations were reported between concern over COVID-19, anxiety, and depression. Regression analyses show adequate model fit (F-test = 76.064, p < .001), where concern about COVID-19 (β =,316, p < .01) and anxiety (β =,417, p < .01), are variables that significantly predict depression in Peruvian nurses (adjusted R2 = .39). Likewise, the t-values of the beta regression coefficients of the predictor variables are highly significant (p < .01). Conclusion: It is concluded that experiencing concern about COVID-19 infection and anxiety predict the occurrence of depressive symptoms in Peruvian nurses that found themselves working in the context of the health emergency.