Title
In vivo estimation of the Young's modulus in normal human dermis
Date Issued
26 October 2018
Access level
metadata only access
Resource Type
conference paper
Publisher(s)
Institute of Electrical and Electronics Engineers Inc.
Abstract
Skin elastic properties change during a cutaneous disorder or in the aging process. Deep knowledge of skin layers helps monitoring and diagnosing structural changes. High frequency ultrasound (HF-US) has been recently introduced to diagnose and evaluate some dermatological disorders in the clinical practice. US elastography adds elasticity information of the analyzed tissue. In particular, harmonic elastography estimates the speed of shear waves produced by external vibration sources, in order to relate the shear wave speed to the Young's modulus. In the epidermis and dermis layers, shear waves are not generated; in contrast, surface acoustic waves (SAWs) exist as they propagate in the top of the tissue. This study uses crawling wave sonoelastography for the estimation of SAWs in human thigh dermis in vivo. Experiments were performed in ten volunteers in the range of 200 - 500 Hz. As other studies suggest, SAW speed needs to be compensated to reach shear wave speed, for calculating the Young's modulus. Thus, the SAW speed estimated was corrected when it propagates in solidUS gel interface. Specifically, the elasticity modulus found was 18.35 ± 1.04 KPa for a vibration frequency of 200 Hz. Results suggest that the elasticity modulus can be estimated in vivo using crawling wave HF-US for skin application and shows potential for future application in skin disorders.
Start page
3456
End page
3459
Volume
2018-July
Language
English
OCDE Knowledge area
Biotecnología relacionada con la salud
Scopus EID
2-s2.0-85056618843
PubMed ID
ISBN
9781538636466
ISSN of the container
1557170X
ISBN of the container
978-153863646-6
Conference
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Sources of information: Directorio de Producción Científica Scopus