Carpal Tunnel Syndrome is the most frequent entrapment neuropathy. It has a wide range of clinical and neurophysiological manifestations which are usually related with the severity of the lesion. Carpal Tunnel Syndrome can occur as an isolated entity or may be associated with polyneuropathies or systemic diseases. This is a prospective study with clinical and neurophysiological correlation of 23 patients (20 female and 3 male) with carpal tunnel syndrome symptomatology. Age ranged between 38 and 83 years old (mean 54.3 ± 10.9). Median time of symptoms was 12 months. Nerve conduction studies of the median, ulnar and common peroneal nerve were practiced in all cases, as well as electromyography of the abductor pollicis brevis, first dorsal interosseous, supinator, brachial biceps and detoid. Clinical analysis showed that 78.26%, of the patients had bilateral lesion even though one side was asymptomatic. Sixty point nine percent of the patients had a manual job. Neurophysiological findings did not correlate with the time and symptoms of the disease. Prolonged motor latencies were present in all cases and correlated with sensor latencies of the median nerve (r 0.71), but conduction velocities were less affected. Electromyography was the least valuable parameter. We conclude that Carpal Tunnel Syndrome is a frequent entity that may be initially unsuspected because of the wide spectrum of manifestations. Electrophysiological studies would permit subclinical cases to be diagnosed and take the best therapeutic option, before an irreversible lesion occurs.