The COVID-19 pandemic forced the use of the virtual in higher education institutions. Entrepreneurship and its various forms are defined under different methods, being indispensable digital technologies. In this sense, the objective of this article is to explain the methodology of research in entrepreneurship, as a strategy for the scientific production of university teachers, particularly in relation to bibliographic databases and videoconferencing. The methodology used is descriptive, with a bibliographic study. The findings are oriented to: 1) development of interactive research on entrepreneurship through the hybrid scientific method, applied to the strategic areas of the territories; 2) transcendental digital transformations directed to bibliographic databases and videoconferencing; 3) research methodology, is key in scientific production and entrepreneurship becomes a transversal axis for the studies developed. It is concluded that the use of bibliographic databases and videoconferencing are inevitable in the university processes of transformation of research and innovation, and particularly the methodology emphasizes the use of digital technologies as a means from the ethical and scientific that corresponds to the new model of educational technology transfer