In this paper, we propose a model to assess the adoption of e-learning tools by professors in the context of COVID-19. The proposed model was constructed by combining three technology adoption models: the Theory of Reasoned Action, the Theory of Planned Behavior, and the Technology Acceptance Model. This study followed a quantitative methodology based on the collection of data from 123 questionnaires administered to professors from different higher education institutions in Medellín (Colombia). According to the results, the variables that most influence the adoption of e-learning tools by professors are compatibility, self-efficacy, previous experience, satisfaction, infrastructure, administrative intervention, social influence, and technical support.