Despite the exuberant figures of those infected and deceased by COVID-19, there are families that were not infected. Objective: To describe the preventive measures and customs in families not infected by COVID-19 during confinement. Method: Descriptive qualitative research, 13 mothers from Ferreñafe with no member affected by COVID-19 participated. The data was collected through the semi-structured interview through telephone calls and processed manually, with thematic content analysis. Results: Four categories were obtained: a) Preventive measures when leaving the home: use of a mask, alcohol and social distancing, b) Preventive measures at home: hand washing, disinfection of the home and what enters, c) Restriction of family gatherings and use of social networks, d) Change of eating habits and use of home remedies. Conclusions: The families changed some customs or practices, complied with the confinement, social distancing, restricted family gatherings, used cloth masks, medicinal alcohol, and bleach. In addition, they increased the frequency of hand washing, home hygiene, healthy eating, the use of social networks, together with the use of home remedies commonly used to prevent or treat respiratory diseases. © 2023 Universidad de Alicante. All rights reserved.