The temporary lockdown of Educational Institutions provoked scenarios of emergency against the Global Crisis of the COVID-19. Which global macrotrends can be applied in the context of a Post COVID-19 pedagogical practices? Three categories were identified: I) Global macrotrends related to the Education Sector; II) The Post COVID-19 pedagogical practice, as a role assumed by the professor involved in the different education spaces (academicist, technological, cultural interpretative, socio-critical and socio-formative); and III) Student Outcomes (SOs), the accreditation model. Global macrotrends were selected to be applied in the post COVID-19 pedagogical practice that contribute to accomplishment of SOs and were consequently classified into three areas: i) Crosscutting Macrotrend (public awareness), ii) the Macrotrend of Post COVID-19 pedagogical practices (Disrupting Education: the assessment of progress, harnessing innovation, multiple senses, co-creation, instant entrepreneurship, the User Experience business-focused model approach for education, and gamification), and iii) the Macrotrend of Support (Networking & Technology).