The association between spirituality and medicine is unfolding as a research theme that may have increasing practical implications in healthcare systems. Both spiritual and scientific dimensions are present within the treatment protocol for addiction applied at the Takiwasi Center, a pioneer therapeutic community that combines western approaches, including psychotherapy, biomedicine, and Catholic practices, with traditional Amazonian medicine. Through a series of open-ended and semi-structured interviews conducted on nine workers of the center during fieldwork research and comparison with the information obtained from literature review, the present article aims at testing the existence of an effective synergy between Catholic religiosity and indigenous-mestizo spirituality within the therapeutic process performed at the Takiwasi Center and puts in evidence some stimulating and problematic issues that arise from this synergy.