Title
Taenia solium and Taenia ovis: Stage-specific expression of the vaccine antigen genes, TSOL18, TSOL16, and homologues, in oncospheres
Date Issued
01 August 2006
Access level
metadata only access
Resource Type
journal article
Author(s)
Universidad Peruana Cayetano Heredia
Johns Hopkins School of Hygiene and Public Health
Abstract
Recombinant antigens that have been cloned from Taenia solium and Taenia ovis have been shown to be highly effective when used as vaccines against cysticercosis in the intermediate hosts. This study investigated the presence of mRNA encoding the TSOL18 and TSOL16 antigens in different life-cycle stages of T. solium, and their related homologues in T. ovis. Reverse transcription-PCR and Southern blotting demonstrated that the antigens are stage-specifically expressed in the oncosphere. The apparent absence of expression of TSOL18 in the metacestode life-cycle stage suggests that the vaccine based on this antigen targets exclusively the early stages in the development of the parasite. © 2006 Elsevier Inc. All rights reserved.
Start page
272
End page
275
Volume
113
Issue
4
Language
English
OCDE Knowledge area
Enfermedades infecciosas
Subjects
Scopus EID
2-s2.0-33746171361
PubMed ID
Source
Experimental Parasitology
ISSN of the container
00144894
Sponsor(s)
This work was funded with research grants from the National Health and Medical Research Council of Australia and the Wellcome Trust. M.V. and R.G. acknowledge support from the Gates Foundation.
Sources of information:
Directorio de Producción Científica
Scopus