The aim of the study was to analyze the relationship between various aspects of the school experience with school satisfaction and overall life satisfaction. Data was collected from a stratified random sample of 1,433 students aged 10 to 14 years (791 men and 642 women) from 3 Chilean cities. The study used the Overall Life Satisfaction Scale (OLS), the General Index of Domains Satisfaction, and the International Survey on Children's Well-Being. Ten predictors were evaluated through multiple linear regression, adjusting models that explained 6% of the variance in OLS and 36% of the variance in school satisfaction. In particular, satisfaction with grades and satisfaction with peers were the best predictors of the models tested. Through binary logistic regression, the adjusted model explained 76% of the variance of school satisfaction, correctly classifying 87% of the cases. Overall, these results identify some determinants in school settings which can affect pupils' satisfaction and which may be used in future research and interventions.