In this study, a new computing paradigm is presented for evaluation of dynamics of nonlinear prey–predator mathematical model by exploiting the strengths of integrated intelligent mechanism through artificial neural networks, genetic algorithms and interior-point algorithm. In the scheme, artificial neural network based differential equation models of the system are constructed and optimization of the networks is performed with effective global search ability of genetic algorithm and its hybridization with interior-point algorithm for rapid local search. The proposed technique is applied to variants of nonlinear prey–predator models by taking different rating factors and comparison with Adams numerical solver certify the correctness for each scenario. The statistical studies have been conducted to authenticate the accuracy and convergence of the design methodology in terms of mean absolute error, root mean squared error and Nash-Sutcliffe efficiency performance indices.