In potato cropping, the opportunity and the number of hillings are directly related to yield, commercial quality, and production costs. The research was carried out with the aim of establishing the effect of the number of hillings on biometric and agronomic characteristics (plant height, number of stems, number of stolons, total yield, and commercial yield) and the profitability index of native potato cultivars. The factors under study were three native potato cultivars: Huayro, Peruanita, and Tumbay, and two hilling moments. The study was conducted under a completely randomized block design with a 3x2 factorial arrangement, and four repetitions. The cultivar interaction by the number of hillings carried out was highly significant for total yield and commercial yield. In the three cultivars, when carrying out one or two hillings, the favorable effect was found in higher total and commercial yields. Concerning the Huayro cultivar, the highest total (kg/ha) and commercial yields (kg/ha) were found when it was hilled on two occasions (p < 0.001). With zero hilling, total yield losses of 86.02 %, 3.67 %, and 47.89 % were observed in the cultivars Huayro, Peruanita, and Tumbay, respectively. In the economic analysis, the Tumbay cultivar recorded the highest rate of return with a single hilling. For the cultivars Huayro and Tumbay, a second hilling was economically unjustified.