Objective: The objective of this study was to explore the psychometric properties of the Scale of Psychological Well-Being for Adults (BIEPS-A) over Mexican students of nursing school. Method: An instrumental case study was made, oriented to the study of the psychometric properties, validity and reliability of the BIEPS-A, in which 228 students from the Nursing School of a public university in Oaxaca, Mexico participated. A confirmatory factorial analysis was executed with the program EQS 6.2, using the robust maximum likelihood method. The oblique model was evaluated in accord with the adjustment indexes, and the intern convergent and discriminant validity was considered. The construct’s reliability was estimated through the ω and H coefficients. Results: It was found that, after the elimination of two items due to their low factorial charge, an adequate adjustment of the internal structure of the BIEPS-A was obtained. The majority of factors showed a prominent average variance extracted (> 0,50), as well as a correct discriminant factors that allowed the independent interpretation of each factor. As for the construct’s reliability, all four factors got acceptable magnitudes (> 0,70), and high magnitudes for the last two (> 0,80). Conclusions: It was concluded that the BIEPS-A has adequate psychometric properties that make it well suited for its incorporation into massive evaluations taken on students, given that it can effectively evaluate the degree of self-reported well-being of the students.