Title
HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis
Date Issued
01 October 2020
Access level
open access
Resource Type
journal article
Author(s)
Loiseau C.
Brites D.
Reinhard M.
Zürcher K.
Borrell S.
Ballif M.
Fenner L.
Cox H.
Rutaihwa L.K.
Wilkinson R.J.
Yotebieng M.
Jane Carter E.
Abimiku A.
Marcy O.
Avihingsanon A.
Zetola N.
Doulla B.
Böttger E.C.
Egger M.
Gagneux S.
Publisher(s)
American Society for Microbiology
Abstract
We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.
Volume
64
Issue
10
Language
English
OCDE Knowledge area
Epidemiología
Salud pública, Salud ambiental
Virología
Enfermedades infecciosas
Subjects
Scopus EID
2-s2.0-85091470049
PubMed ID
Source
Antimicrobial Agents and Chemotherapy
ISSN of the container
00664804
Sponsor(s)
This research was supported by the Swiss National Science Foundation (grant numbers 153442, 310030_188888, 174281, and IZRJZ3_164171). The International Epidemiology Databases to Evaluate AIDS (IeDEA) is supported by the U.S. National Institutes of Health’s National Institute of Allergy and Infectious Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Cancer Institute, the National Institute of Mental Health, the National Institute on Drug Abuse, the National Heart, Lung, and Blood Institute, the National Institute on Alcohol Abuse and Alcoholism, the National Institute of Diabetes and Digestive and Kidney Diseases, the Fogarty International Center, and the National Library of Medicine:
Asia-Pacific, U01AI069907; CCASAnet, U01AI069923; Central Africa, U01AI096299; East Africa, U01AI069911; NA-ACCORD, U01AI069918; Southern Africa, U01AI069924; and West Africa, U01AI069919. Informatics resources are supported by the Harmonist Project, R24AI124872. This work is solely the responsibility of the authors and does not necessarily represent the official views of any of the institutions mentioned above. R.J.W. is supported by the Francis Crick Institute, which receives funding from Wellcome (FC0010218), CRUK (FC0010218), and UKR1 (FC0010218). He is also supported by Wellcome (104803 and 203135).
Sources of information:
Directorio de Producción Científica
Scopus