Title
Diagnosis of plasmodium vivax by loop-mediated isothermal amplification in febrile patient samples from loreto, PerĂº
Date Issued
01 October 2020
Access level
open access
Resource Type
journal article
Author(s)
Publisher(s)
American Society of Tropical Medicine and Hygiene
Abstract
Plasmodium vivax is co-endemic with Plasmodium falciparum in Peru, and optimum management requires distinguishing these two species in the blood of patients. For the differential identification of P. vivax and other Plasmodium spp., the LoopampTM Malaria Pan Detection Kit in combination with the Loopamp Malaria Pv Detection Kit (Eiken Chemical Co. Ltd., Tokyo, Japan) was used to evaluate 559 whole blood samples collected in 2017 from febrile patients with suspected malaria attending different health facilities in the Loreto region. The Loopamp Malaria Pan Detection Kit showed a sensitivity of 87.7% (95% CI: 83.5-91.9) and a specificity of 94.4% (95% CI: 91.9-96.9) and good agreement with PCR (Cohen's kappa 0.8266, 95% CI: 0.7792-0.874). By comparison, the Loopamp Malaria Pv Detection Kit showed a similar sensitivity (84.4%, 95% CI: 79.0-89.7) and specificity (92.4%, 95% CI: 89.7-95.0) and substantial agreement with PCR (Cohen's kappa: 0.7661, 95% CI: 0.7088-0.8234).
Start page
1549
End page
1552
Volume
103
Issue
4
Language
English
OCDE Knowledge area
Medicina general, Medicina interna
Scopus EID
2-s2.0-85092693504
PubMed ID
Source
American Journal of Tropical Medicine and Hygiene
ISSN of the container
00029637
Sources of information:
Directorio de ProducciĂ³n CientĂfica
Scopus