Methicillin-resistant Staphylococcus aureus (MRSA) is an important and growing cause of infection in hospital-associated settings and, more recently, in the community, both globally and in Latin America.1-3 Infections with MRSA and other antibiotic-resistant Gram-positive organisms are challenging to treat and impose a high burden on healthcare resources. The Latin American Working Group on Gram-positive resistance was established in 2007, with the aims of reducing this burden and improving the overall management of infections due to Gram-positive resistant bacteria in the region. The group consists of 11 physicians from Latin America with interest and expertise in these issues.