The aim of the current research was the isolation, characterization and identification of native microbial strains from waste generated in the processing of sheep wool and alpaca fiber, for the production of biogas inside a dry anaerobic digestion (DAD) reactor in order to degrade solid waste coming from the textile industry. In total 52 bacterial strains and 15 fungal strains were isolated in anaerobic conditions from samples taken from solid waste produced in the processing of alpaca fiber and sheep wool by the Inca Tops textile company. Both the biogas composition and production were evaluated in 3 DAD reactors with different inocula: bacteria, fungi and microbial consortia; with the consortium inoculated reactor having the best production rate and best biogas attributes obtaining 33.38 %, 6 %, 1.44 % and 0.89 ppm methane, carbon dioxide, oxygen, and hydrogen sulfide respectively