Title
Feasibility of Fully Closed Loop Insulin Delivery in Type 2 Diabetes
Date Issued
01 August 2019
Access level
metadata only access
Resource Type
conference paper
Author(s)
Ornetzeder C.
Reiterer F.
Christensen M.B.
Norgaard K.
Freckmann G.
Universidad Johannes Kepler de Linz
Publisher(s)
Institute of Electrical and Electronics Engineers Inc.
Abstract
Because of continuous technical progress over the last decades artificial pancreas (AP) systems have recently become reality for patients with type 1 diabetes (T1D) with first AP devices entering the market. However, all AP systems commercially under development are so-called hybrid closed loop systems, meaning that only the basal insulin is adjusted by the algorithm, whereas the meal boluses still have to be triggered manually by the patient. Fully closed loop systems for T1D that also administer meal boluses autonomously are so far mainly of academic interest. The biggest drawback of fully closed loop systems is that they can only give an insulin bolus as soon as a meal is detected from the recorded data, leading to significant delays in insulin delivery (and therefore more pronounced peaks in postprandial glucose) and/or an increased risk of hypoglycemia (in case of false positive detections). Contrary to almost all publications on the topic, the current paper investigates the feasibility of fully closed loop systems for patients with type 2 diabetes (T2D). Since glycemic variability tends to be significantly lower in T2D and since glucose dynamics are somewhat slower, fully closed loop systems seem in fact more favorable for this patient group than for T1D. The paper investigates the performance of available meal detection algorithms from the literature (developed for T1D patients) and modifies them for application in T2D. Additionally, the paper proposes a simple fully closed loop algorithm for T2D patients including a module for automatic meal bolusing and demonstrates its feasibility and safety.
Start page
906
End page
913
Language
English
OCDE Knowledge area
Endocrinología, Metabolismo (incluyendo diabetes, hormonas)
Scopus EID
2-s2.0-85077791269
Resource of which it is part
CCTA 2019 - 3rd IEEE Conference on Control Technology and Applications
ISBN of the container
9781728127675
Conference
3rd IEEE Conference on Control Technology and Applications, CCTA 2019
Sources of information: Directorio de Producción Científica Scopus