Title
Antibiotic activity of Emerimicin IV isolated from Emericellopsis minima from Talcahuano Bay, Chile
Date Issued
03 June 2018
Access level
open access
Resource Type
journal article
Author(s)
Inostroza A.
Lara L.
Paz C.
Perez A.
Hernandez V.
Becerra J.
González-Rocha G.
Silva M.
Universidad de Concepción
Publisher(s)
Taylor and Francis Ltd.
Abstract
Due to the increasing emergence of resistance of bacterial pathogens to current antibiotics, we have examined the marine fungi present in sea sediments obtained 200 m offshore to discover new antibacterial compounds active against multidrug-resistant bacteria. One strain, identified as Emericellopsis minima, was isolated from sediments of Talcahuano Bay (Chile). From the liquid culture of E. minima, we isolated Emerimicin IV, a unique fungal peptaibol that exhibited antibacterial activity. The structure of this compound was assigned by interpretation of 1H NMR and HR-LCMS data. Emerimicin IV showed bacteriostatic activity against clinical isolates of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis with MIC values ranging between 100 and 12.5 μg/mL.
Start page
1361
End page
1364
Volume
32
Issue
11
Language
English
OCDE Knowledge area
Biología celular, Microbiología
Patología
Farmacología, Farmacia
Subjects
Scopus EID
2-s2.0-85021801568
PubMed ID
Source
Natural Product Research
ISSN of the container
14786419
Sponsor(s)
This work was supported by FONDECYT [grant number 1120924]; Dirección de Investigación, Universidad de Concepción [grant number Enlace N°215.111.060-1.0].
We appreciate the financial support provided by the projects FONDECYT N°1120924, and Enlace-Universidad de Concepción N°215.111.060-1.0, which made this work possible. Finally, we thank Zenon Rozas and Magda Hernandez for their technical assistance.
This work was supported by FONDECYT [grant number 1120924]; Direcci?n de Investigaci?n, Universidad de Concepci?n [grant number Enlace N?215.111.060-1.0]. We appreciate the financial support provided by the projects FONDECYT N?1120924, and Enlace-Universidad de Concepci?n N?215.111.060-1.0, which made this work possible. Finally, we thank Zenon Rozas and Magda Hernandez for their technical assistance.
Sources of information:
Directorio de Producción Científica
Scopus