Title
A new multiple classifier system for the prediction of protein's contacts map
Date Issued
01 December 2015
Access level
metadata only access
Resource Type
journal article
Author(s)
University of Ciego de Ávila
University of Pablo de Olavide
Publisher(s)
Elsevier B.V.
Abstract
In this paper, we introduce FoDT, a new algorithm for the prediction of proteins contact map, one of the great challengers of the Bioinformatics. The need of more accurate predictions, aims to combining classifiers, beyond complexity increase. The proposed methodology can be considered as a set of cooperative classifiers, which employs a not trainable combination method and coverage optimization. The robustness and predictivity evaluation, with the dataset of 9th Critical Assessment of Techniques for Protein Structure Prediction, demonstrates that our algorithm can assign contacts with an average accuracy up to 58%. It performs similarly to free servers as SVM-SEQ, NNcon and LRcon, and overcoming FragHMMent. The FoDT main advantage is their capability to break down the complex process of protein folding into a collection of simple decision rules, providing a more easy and interpretable solution for the prediction of contact's maps.
Start page
983
End page
990
Volume
115
Issue
12
Language
English
OCDE Knowledge area
Informática y Ciencias de la Información
Subjects
Scopus EID
2-s2.0-84984558767
Source
Information Processing Letters
ISSN of the container
00200190
Sources of information:
Directorio de Producción Científica
Scopus