The use of agrochemicals such as azole antifungals against plant diseases has direct economic benefits to the minimization of losses in crops. However, one of the disadvantages is that strains can develop resistance to this pesticide. The application of nanotechnology in agriculture has gained more attention for improving crop production. Particularly, due to its antimicrobial properties, copper-based nanostructures are excellent alternatives to control plant diseases. However, there are few studies on its benefits in the control of diseases in plants. This chapter describes the use of copper-based nanostructure against different plant diseases.