The Neotropics harbour a spectacular amount of biodiversity, but many of these species remain to be discovered and placed into the tree of life. In the neotropical snake genus Philodryas, the systematics of these rear-fanged snakes has been controversial and debated in recent years. Here, we combine published datasets with new morphological (scale microdermatoglyphics, osteology, pholidosis and genital features) and molecular (mitochondrial and nuclear) data to reassess the phylogenetic positioning of rear-fanged snakes within the tribe Philodryadini. We identified putative synapomorphies and pronounced morphological variation in hemipenial features. Our results suggested a need to reclassify many species in order to clarify some relationships within the Philodryas radiation. We also redefined Philodryadini by resurrecting three genera and naming a newly discovered species.