Title
Preliminary Results on the Regulatory Role of IFN-γ and IL-10 Human Schistosomiasis Mansoni
Date Issued
01 January 1998
Access level
open access
Resource Type
journal article
Author(s)
Montenegro S.M.L.
Miranda P.
Abath F.G.C.
Teixeira K.M.
Coutinho E.M.
Domingues A.L.C.
Domingues L.
Brinkman J.
Gonçalves I.
Sher A.
Wynn T.A.
Centers for Disease Control
Publisher(s)
Fundacao Oswaldo Cruz
Abstract
Studies about in vivo IL-10 immunoregulation demonstrated that CD4+ cells from Schistosoma mansoni infected mice produced large amounts of
IL-10 and that this response was temporally and mechanistically linked to the downregulation of the Th1 cytokine response (A Sher et al. 1991 J Immunol 147: 2713-2716). The addition of neutralizing anti IL-10 mAb to the cultures resulted in an increase in IFN-g production to levels approaching those seen before the egg laying phase (EJ
Pearce & A Sher 1991
Start page
173
End page
180
Volume
93 SUPPL. 1
Language
English
OCDE Knowledge area
Inmunología
Subjects
Scopus EID
2-s2.0-0032253105
PubMed ID
Source
Memorias do Instituto Oswaldo Cruz
Resource of which it is part
Memorias do Instituto Oswaldo Cruz
ISSN of the container
00740276
Sources of information:
Directorio de Producción Científica
Scopus