The demand for energy grows along with the number of studies in the field of alternative energy. Clean energy has been the goal of numerous studies and it has been encouraged, seen by the gradual migration from conventional to hybrid or purely electric vehicles. Although clean energy is desirable, we continue to rely on traditional fuel. Thus, this work aims to improve the efficiency and minimize the polluting effects of the fuels in internal combustion engines. Using the combustion mode of reactivity-controlled compression ignition, in which two different fluids, with distinct auto-ignition characteristics, are injected into the combustion chamber, at different times, aiming to burn the fuel at a lower power of auto-ignition. Parameters such as the amount of fuel and start of injections points (SOIs) have substantial influence on the overall process. Performance, emissions, combustion noise and others characteristics are mainly influenced by the ignition delay. The ignition delay in a diesel engine is defined as the interval of time between the start of fuel injection and the combustion. Therefore, with the SOI of the fuel with lower enthalpy of vaporization and the start of combustion, the ignition delay can be inferred. The results show the influence of different parameters, such as compression ratio, start of fuel injections, injection strategies of two different fuels, in this case, hydrous ethanol and diesel, on the combustion process. The results are presented for compression ratios of 16:1 and 20:1.