Title
CoDNaS-RNA: A database of conformational diversity in the native state of RNA
Date Issued
15 March 2022
Access level
open access
Resource Type
journal article
Author(s)
González Buitrón M.
Tunque Cahui R.R.
Garciá Ríos E.
Parisi G.
Fornasari M.S.
Palopoli N.
Publisher(s)
Oxford University Press
Abstract
Summary: Conformational changes in RNA native ensembles are central to fulfill many of their biological roles. Systematic knowledge of the extent and possible modulators of this conformational diversity is desirable to better understand the relationship between RNA dynamics and function. We have developed CoDNaS-RNA as the first database of conformational diversity in RNA molecules. Known RNA structures are retrieved and clustered to identify alternative conformers of each molecule. Pairwise structural comparisons between all conformers within each cluster allows to measure the variability of the molecule. Additional annotations about structural features, molecular interactions and biological function are provided. All data in CoDNaS-RNA is free to download and available as a public website that can be of interest for researchers in computational biology and other life science disciplines.
Start page
1745
End page
1748
Volume
38
Issue
6
Language
English
OCDE Knowledge area
Bioinformática Bioquímica, Biología molecular
Scopus EID
2-s2.0-85126636308
Source
Bioinformatics
ISSN of the container
13674803
Sponsor(s)
This work was supported by Universidad Nacional de Quilmes [PUNQ 1309/19]; Agencia Nacional de Promocio´n de la Investigacio´ n, el Desarrollo Tecnolo´ gico y la Innovacio´ n [PICT-2018 3457]; and Consejo Nacional de Investigaciones Cientıficas y Tecnicas (CONICET) [PIP-2015-2017 11220150100853CO] from Argentina. M.G.B. is a PhD Fellow and M.S.F., G.P. and N.P. are Researchers from CONICET.
Sources of information: Directorio de Producción Científica Scopus