This article focuses on the three-dimensional Cross fluid flow of a radiative nanofluid over an expanding sheet with aligned magnetic field, chemical reaction, and heat generation phenomenon. The stretching sheet has convective heat and slip boundary conditions. The similarity variables are properly used for the conversion of a dimensional mathematical model into a nondimensional one. The transformed ordinary differential equations are handled for the numerical outcomes of the suggested fluidic model by incorporating the shooting scheme. Furthermore, the numeric investigations are also compared by bvp4c MATLAB built-in package. In a limited case, both the techniques are checked with already published articles, thereby revealing good agreement. Furthermore, the effects of few parameters like Prandtl number, Weissenberg number, heat generation, stretching rate parameter, magnetic parameter, thermal radiation, Brownian and thermophoresis parameters, and Lewis number on concentration, temperature, and velocity profiles have been presented using figures and numerical tables. The strong intensity of the magnetic field across the fluid and increment in the inclination angle (ϑ) result in a lower velocity profile. Temperature is more prominent for the higher slip mechanism. Furthermore, there in an increase in thermophoretic force, which pushes the nanoparticles, and this mixing of nanoparticles helps to increase the concentration profile. A higher Cross fluid index responds to a larger velocity.