The sciences that universities and scientific societies developed during the modern era underwent a radical transformation over the twentieth century. They experienced a structural mutation that affects, above all, the organization of scientific practice, as well as the ways of producing, distributing, teaching, and using scientific knowledge. As a result, the technosciences, a hybrid between science and technology, have appeared. Because science has changed, the philosophy of science must also change. These are the basic hypotheses that I will use as a starting point for this contribution. This paper has been written in the framework of the Research Project FFI 2008- 03599/FISO financed by the Spanish Ministry of Science and Innovation.