Objective: To determine the influence of teleworking on Burnout Syndrome (BS) among employees in the Call Center sector in Chiclayo, Peru. This need arose because COVID-19 altered routines and increased stress, significantly impacting workers' health. Methods: The research implemented a non-experimental, quantitative, cross-sectional, and causal-propositive correlational design. A probabilistic sample of 183 teleworkers from a total population of 350 was selected. For data collection, a survey and a virtual questionnaire were applied. The instruments were validated by eight experts, and their reliability was obtained using Cronbach's Coefficient. Results: The most notable findings revealed that the efficiency of teleworking was classified as deficient by 3.3% of respondents, moderate by 21.3%, and efficient by 75.4%. In relation to BS, 68.3% of participants rated their level as low, 29.0% as medium, and 2.7% as high. To contrast the hypotheses, Spearman's Rho correlation coefficient was used. Conclusions: Teleworking significantly inversely influences BS among the study's Call Center sector employees. A low correlation degree of r =-0.296 was observed, with a bilateral significance level of 0.01, suggesting that an increase in teleworking efficiency may be related to a decrease in the prevalence of BS. © 2023, Editorial Ciencias Medicas. All rights reserved.