In this study, we examined the impact of childhood interpersonal adversity on adulthood subjective well-being (SWB), with a focus on the mediating and moderating effects of social support and socioeconomic status (SES). We concentrated on parental maltreatment (abuse and neglect) and bullying in school as childhood adversity variables and on perceived happiness and self-rated health as adulthood SWB measures. Our empirical analysis was based on micro data from a survey in municipalities in and around the Tokyo metropolitan area (N = 3,292). We obtained four key findings. First, the experience of childhood adversity had a substantial negative impact on adulthood SWB. Second, social support and SES significantly mediated the impact of childhood adversity. Third, however, a large proportion of the impact of childhood adversity remained unexplained by their mediation effects. Fourth, social support and SES did not moderate the impact of childhood adversity. Hence, we can conclude that childhood adversity affects adulthood SWB in a relatively independent manner rather than being substantially mediated or moderated by social support or SES. Accordingly, social policies should aim at reducing incidents of childhood maltreatment and bullying in addition to helping people enhance levels of social support and SES in later life. © 2012 Springer Science+Business Media B.V.