This paper presents the interrelationship between the equatorial electrojet (EEJ) strength, Global Positioning System (GPS)-derived total electron content (TEC), and postsunset scintillation from ground observations with the aim of finding reliable precursors of the occurrence of ionospheric irregularities. Mutual relationship studies provide a possible route to predict the occurrence of TEC fluctuation and scintillation in the ionosphere during the late afternoon and night respectively based on daytime measurement of the equatorial ionosphere. Data from ground based observations in the low latitudes of the west American longitude sector were examined during the 2008 solar minimum. We find a strong relationship exists between the noontime equatorial electrojet and GPS-derived TEC distributions during the afternoon mediated by vertical E × B drift via the fountain effect, but there is little or no relationship with postsunset ionospheric scintillation.