The main characteristics of photovoltaic (PV) energy and its current development in Latin American and Caribbean countries (LAC); its impact on the electrification of homes, health institutions, and schools in isolated or difficult-to-access communities; and, the advantages thereof are presented and discussed by replacing the use of traditional fuels such as firewood and kerosene in order to improve inhabitants ’health as well as reducing CO2 emissions. Countries like Nicaragua, Peru, Brazil, Argentina, and Chile stand out for their growing PV energy development in the region. A case study of the electrification process by PV systems shows very positive changes are manifested in terms of improving the quality of life of the inhabitants, and especially their physical and mental health state. In addition, CO2 emission reductions from electrifying 216 houses in the nine communities reach an annual amount of 2,164.19 t/yr, reducing firewood consumption by 2,123.39 t/yr and kerosene consumption by 40.80 t/yr However, LAC countries must adopt laws and regulations that regulate the use of PV energy, with an emphasis on recycling systems at the end of their life cycle.