Title
Essential oil from the leaves of Xylopia langsdorfiana (Annonaceae) as a possible spasmolytic agent
Date Issued
19 May 2015
Access level
metadata only access
Resource Type
journal article
Author(s)
Correia A.
Ferreira T.
Martins I.
Macêdo C.
Monteiro F.
Costa V.
Tavares J.
Silva M.
Buri M.
Rigoni V.
Nouailhetas V.
Da Silva B.
Federal University of São Paulo
Publisher(s)
Taylor and Francis Ltd.
Abstract
Xylopia langsdorfiana A. St.-Hil. &Tul. (Annonaceae) is popularly known in the northeast of Brazil as pimenteira da terra, and an essential oil (XL-OE) was extracted from its leaves. Since Xylopia species are cited in folk medicine and diterpenes from X. langsdorfiana have spasmolytic activity, this study aimed to investigate a possible spasmolytic action of XL-OE on smooth muscle models. XL-OE (243 and 729 g/mL) showed low pharmacologic efficacy on guinea pig trachea and rat aorta and uterus. However, in guinea pig ileum, XL-OE (27-729 g/mL) inhibited carbachol or histamine-induced phasic contractions (1 M) in a significant and concentration-dependent manner. In addition, XL-OE (81 g/mL) reduced fluorescence intensity in ileal myocytes stimulated by histamine, indicating a decrease in cytosolic calcium concentration, which could explain the spasmolytic activity. Thus, XL-OE proved to be a promising natural product to be used in gastrointestinal diseases acting by modulating the cytosolic calcium concentration.
Start page
980
End page
984
Volume
29
Issue
10
Language
English
OCDE Knowledge area
Bioquímica, Biología molecular
Ciencias de las plantas, Botánica
Subjects
Scopus EID
2-s2.0-84937511548
PubMed ID
Source
Natural Product Research
ISSN of the container
14786419
Sponsor(s)
The authors thank CAPES and CNPq for financial support.
Sources of information:
Directorio de Producción Científica
Scopus