The behavior of physical-chemical parameters and potentially toxic metals in the surface water of Lake Chinchaycocha was evaluated using multimetric indices between March and December 2018. Water samples were collected from 10 sampling sites during the rainy and low-water periods, and water quality was determined using the WQI CCME and the Shannon-Wiener index, followed by multivariate analysis. The WQI CCME rated good quality water, except for the LCh1 site. The Shannon-Wiener index rated moderate and extremely contaminated water. The cluster analysis grouped the sampling sites into two clusters with similar characteristics. The ACP presented a total percentage variation of 76.07%. Therefore, this study provides an updated state of the water quality of Lake Chinchaycocha using different indices and multivariate techniques.