This study aims to identify factors contributing to the development of community-acquired infections in hospitalized type-2 diabetics, using an unmatched case-control design. A total of 105 pairs of diabetic patients with community-acquired infections as compared to non-infectious diseases, respectively, were chosen randomly from the discharge registry of the clinical wards of a teaching hospital from 1991 to 1998. Bivariate and multivariate analysis was conducted with estimation of the adjusted odds ratio. According to stratified analysis controlling for age and sex, autonomic neuropathy proved to be a contributing factor to development of urinary tract infections (OR = 4.07). In the multivariate model, peripheral vasculopathy was isolated (R2: 0.24) as a contributing factor in the development of soft-tissue infections (OR = 6.79). Confidence intervals were significant at 0.05. In conclusion, peripheral vasculopathy and neurogenic bladder contribute to the development of community-acquired infections in hospitalized type-2 diabetics.