Title
Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission
Date Issued
01 May 2011
Access level
open access
Resource Type
journal article
Author(s)
Schwarz A.
Richards J.
Rath B.
Machaca V.Q.
Castro Y.E.
Levy K.
Bern C.
Universidad Peruana Cayetano Heredia
Johns Hopkins University
University of Pennsylvania
Abstract
Insecticide-impregnated nets can kill triatomine bugs, but it remains unclear whether they can protect against Chagas disease transmission. In a field trial in Quequeña, Peru, sentinel guinea pigs placed in intervention enclosures covered by deltamethrin-treated nets showed significantly lower antibody responses to saliva of Triatoma infestans compared with animals placed in pre-existing control enclosures. Our results strongly suggest that insecticide-treated nets prevent triatomine bites and can thereby protect against infection with Trypanosoma cruzi. Anti-salivary immunoassays are powerful new tools to evaluate intervention strategies against Chagas disease. © 2011 Australian Society for Parasitology Inc.
Start page
591
End page
594
Volume
41
Issue
6
Language
English
OCDE Knowledge area
Enfermedades infecciosas
Inmunología
Subjects
Scopus EID
2-s2.0-79954850719
PubMed ID
Source
International Journal for Parasitology
ISSN of the container
00207519
Sponsor(s)
We thank the community of Quequeña for their participation. We especially thank Rocio Rodriguez, Amparo Toledo and the sprayers and field collectors who worked on the study. We also thank Gregory Martin, Jeffrey Stancil, David Bentzel, Ellen Dotson, Robert Wirtz, Lucy Rubio, Gena Lawrence, Karina Oppe and Fernando Malaga for assistance and support. The authors thank Torben Frandsen for fabrication and donation of the guinea pig PermaNets, and Jesus Valenzuela for his advice and support. We would also like to thank the Pan American Health Organization (PAHO), the Canadian International Development Agency (CIDA), Ministerio de Salud del Perú (MINSA), Dirección General de Salud de las Personas (DGSP), Estrategia Sanitaria Nacional de Prevención y Control de Enfermedades Metaxénicas y Otras Transmitidas por Vectores (ESNPCEMOTVS), Dirección General de Salud Ambiental (DIGESA), Gobierno Regional de Arequipa and the Gerencia Regional de Salud de Arequipa (GRSA). Funding for this study came from NIH 5K01 AI079162-03, NIH 3K01AI079162-02S1, 3K01AI079162-03S1 and NIH P50 AI074285-04. This study also received financial support from the UNICEF/UNDP/World Bank/WHO Special Program for Research and Training in Tropical Diseases (TDR Grant) and the Grant Agency of the Czech Republic , Grant No. P302/11/P798.
Sources of information:
Directorio de Producción Científica
Scopus