The case evaluated hereunder is that of a young patient, from a Histoplasmosis-endemic area, reporting chronic abdominal pain. An upper gastric endoscopy evidenced the presence of gastric compromise, characterized by evident infiltrating ulcerous damage simulating a carcinoma. The final diagnosis was chronic disseminated histoplasmosis with gastric compromise. The patient presented as an underlying condition, a chronic alcoholic hepatopathy. Histoplasmosis must be included in the differential diagnosis of ulcerated and/or infiltrated lesions of the gastrointestinal tract in patients from endemic areas or susceptible to immunosuppression conditions.