Title
Electrochemical determination of paracetamol in a pharmaceutical dose by adsorptive voltammetry with a carbon paste/La2O3microcomposite
Date Issued
28 May 2020
Access level
metadata only access
Resource Type
journal article
Publisher(s)
Royal Society of Chemistry
Abstract
This paper presents a new application for microcomposites based on carbon paste (CP) and La2O3 (LaOX). This simple and versatile microcomposite (LaOX/CPE) was applied toward the determination of paracetamol (PCM) through proton oxidation by square wave adsorptive voltammetry (SWAdV). The anodic peak current for PCM increased by nearly 70.0% compared with an unmodified CP, and the detection limit was 0.020 μmol L-1. The relative standard deviations (RSDs) were 1.0% (n = 7). The accuracy of the new method was evaluated with tap water spiked with known quantities of PCM, while ascorbic acid, caffeine, and acetylsalicylic acid were used for interference studies. Finally, the usefulness of the microcomposite was shown to have acceptable results when applied to detect and quantify PCM in various forms of a pharmaceutical dose, such as solid tablets, fruit-flavored powders for colds and syrups for children.
Start page
2608
End page
2613
Volume
12
Issue
20
Language
English
OCDE Knowledge area
Electroquímica Farmacología, Farmacia
Scopus EID
2-s2.0-85089570915
PubMed ID
Source
Analytical Methods
ISSN of the container
17599660
Sponsor(s)
This study was funded by the Universidad Nacional Mayor de San Marcos (project C1907068118-541). Additionally, thanks to the Universidad de los Andes, Science Faculty and the Chemistry Department for providing funding (project no. INV-2018-50-1354).
Sources of information: Directorio de Producción Científica Scopus