Introduction: The context of the pandemic has generated important changes in health professionals who work in hospital settings, especially in nursing personnel who are in the first line, facing stressful situations that have a direct impact on the degree of job satisfaction. Objective: Determine the relationship between work stressors and the satisfaction of Peruvian nurses in the context of the COVID-19 pandemic. Methods: Cross-sectional, correlational and analytical study carried out in 60 nurses who work in critical services of a public hospital in Chimbote (Peru). The Nursing Stress Scale and Internal User Satisfaction Survey questionnaires were used, with a Likert-type scale and which were adapted to the Peruvian context. The variables were expressed in percentages, and Pearson's bivariate correlation test was used to establish an association. A significance level of p <0.05 was assumed. Results: The medium level prevailed in the environmental (63.33%), work (83.33%) and personal (51.67%) stressors of the nursing professionals. A significant association was found between job satisfaction and environmental stressors (p <0.01) and personal (p <0.05). Conclusions: The environmental and personal factor in Peruvian nurses who are working in direct patient care in the COVID-19 context is associated with job satisfaction.