Title
Porcine cysticercosis: Possible cross-reactivity of taenia hydatigena to GP50 antigen in the enzyme-linked immunoelectrotransfer blot assay
Date Issued
01 January 2017
Access level
open access
Resource Type
journal article
Author(s)
Muro C.
Flecker R.
Barreto P.
Dorny P.
Tsang V.
O'Neal S.
Publisher(s)
American Society of Tropical Medicine and Hygiene
Abstract
The lentil lectin glycoprotein enzyme-linked immunoelectrotransfer blot (LLGP EITB, reported sensitivity 99% and specificity 100%) is used as a serologic marker of exposure to Taenia solium in pigs. However, only a limited number of parasites have been evaluated for cross reactivity. Pigs may host other related cestode infections, including Taenia hydatigena, which have not been formally evaluated for cross-reactions.Weinvestigated a corral in Tumbes, Peru, a region where a cysticercosis elimination demonstration project was completed in 2012. In this corral, 14/19 (73.7%) 6-8-week-old piglets were reactive to GP50 on LLGP EITB, and all had circulating Taenia sp. antigens. From eight necropsied piglets; four were infected with T. hydatigenametacestodes whereas none had evidence of T. solium infection. Two resident dogs were subsequently confirmed to have T. hydatigena taeniasis. These results suggest GP50 crossreactivity in T. hydatigena-infected pigs, although controlled experimental infection is needed to confirm this hypothesis.
Start page
1830
End page
1832
Volume
97
Issue
6
Language
English
OCDE Knowledge area
Parasitología
Scopus EID
2-s2.0-85037041882
PubMed ID
Source
American Journal of Tropical Medicine and Hygiene
ISSN of the container
00029637
Sponsor(s)
Financial support: This research was made possible with support from the Fogarty International Center (FIC) and the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) grant number R21AI119438. Partial support from Training grant TW001140 from the Fogarty International Center in training of study team members is also acknowledged.
National Institute of Allergy and Infectious Diseases R21AI119439
National Institute of Neurological Disorders and Stroke R01NS080645
Medical Research Council MR/K007467/1
Sources of information:
Directorio de Producción Científica
Scopus