Title
Streptococcus pyogenes pbp2x mutation confers reduced susceptibility to ß-lactam antibiotics
Date Issued
01 July 2020
Access level
open access
Resource Type
journal article
Author(s)
Vannice K.S.
Nanduri S.
Fang F.C.
Lynch J.B.
Bryson-Cahn C.
Wright T.
Duchin J.
Kay M.
Chochua S.
van Beneden C.A.
Beall B.
National Center for Immunization and Respiratory Diseases
Publisher(s)
Oxford University Press
Abstract
Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step in developing ß-lactam resistance.
Start page
201
End page
204
Volume
71
Issue
1
Language
English
OCDE Knowledge area
Tecnología para la identificación y funcionamiento del ADN, proteínas y enzimas y como influencian la enfermedad)
Enfermedades infecciosas
Scopus EID
2-s2.0-85091772870
PubMed ID
Source
Clinical Infectious Diseases
ISSN of the container
10584838
Sources of information:
Directorio de Producción Científica
Scopus