The present study aimed to evaluate the effect of cataplasm of Annona muricata L. leaves on second degree burns induced in a rat model. 32 specimens Rattus norvegicus albino, which were randomly distributed in four groups of 8 specimens, including the healthy, control, experimental (Annona muricata L.) and standard (silver sulfadiazine) groups. The treatments were topical and for 15 days. An experimental model was used for the induction of second-degree burns, by means of thermal burn. The variation of the burned body area (mm2) at the lateral and craniocaudal level was evaluated daily and measurements of the lesions were carried out to control the healing during 15 days, then the histopathological study was carried out. In addition, a phytochemical study was carried out. The results show a significant reduction in the body area burned in the experimental and standard groups compared to the control group (p <0.05), which is reinforced by the histopathological findings such as a decrease in blood vessels, fibroblasts and the presence of macrophages in the standard group, as well as a reticular-like chorion, greater presence of collagen and scarce fibroblasts and scarce blood vessels in the experimental group (A. muricata L) indicative of intense repair. Likewise, an abundant presence of flavonoids, tannins, alkaloids among other secondary metabolites was found in the leaves of A. muricata L. Annona muricata L leaves, administered topically, in the form of a cataplasm, revealed a healing effect on second-degree burns induced in the experimental model studied. Further studies are required to elucidate its mechanism of action and specifically determine the active principles responsible.