Title
Sleep disorders associated with Alzheimer's disease: A perspective
Date Issued
31 May 2018
Access level
open access
Resource Type
research article
Author(s)
Brzecka A.
Leszek J.
Ashraf G.M.
Ejma M.
Ávila-Rodriguez M.F.
Yarla N.S.
Tarasov V.V.
Chubarev V.N.
Samsonova A.N.
Aliev G.
Pontificia Universidad Javeriana
Abstract
Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative disease. Here, we describe clinical features of sleep disorders in AD and the relation between sleep disorders and both cognitive impairment and poor prognosis of the disease. There are difficulties of the diagnosis of sleep disorders based on sleep questionnaires, polysomnography or actigraphy in the AD patients. Typical disturbances of the neurophysiological sleep architecture in the course of the AD include deep sleep and paradoxical sleep deprivation. Among sleep disorders occurring in patients with AD, the most frequent disorders are sleep breathing disorders and restless legs syndrome. Sleep disorders may influence circadian fluctuations of the concentrations of amyloid-β in the interstitial brain fluid and in the cerebrovascular fluid related to the glymphatic brain system and production of the amyloid-β. There is accumulating evidence suggesting that disordered sleep contributes to cognitive decline and the development of AD pathology. In this mini-review, we highlight and discuss the association between sleep disorders and AD.
Volume
12
Issue
MAY
Language
English
OCDE Knowledge area
Neurociencias
Scopus EID
2-s2.0-85047869142
Source
Frontiers in Neuroscience
ISSN of the container
16624548
Sources of information: Directorio de Producción Científica Scopus