Title
Genetic diversity and population structure of genes encoding vaccine candidate antigens of Plasmodium vivax
Date Issued
15 March 2012
Access level
open access
Resource Type
journal article
Author(s)
Tapia L.L.
Escalante A.A.
Bacon D.J.
Unidad de Investigaciones Médicas Navales No. 6
Unidad de Investigaciones Médicas Navales No. 6
Abstract
Background: A major concern in malaria vaccine development is genetic polymorphisms typically observed among Plasmodium isolates in different geographical areas across the world. Highly polymorphic regions have been observed in Plasmodium falciparum and Plasmodium vivax antigenic surface proteins such as Circumsporozoite protein (CSP), Duffy-binding protein (DBP), Merozoite surface protein-1 (MSP-1), Apical membrane antigen-1 (AMA-1) and Thrombospondin related anonymous protein (TRAP). Methods. Genetic variability was assessed in important polymorphic regions of various vaccine candidate antigens in P. vivax among 106 isolates from the Amazon Region of Loreto, Peru. In addition, genetic diversity determined in Peruvian isolates was compared to population studies from various geographical locations worldwide. Results: The structured diversity found in P. vivax populations did not show a geographic pattern and haplotypes from all gene candidates were distributed worldwide. In addition, evidence of balancing selection was found in polymorphic regions of the trap, dbp and ama-1 genes. Conclusions: It is important to have a good representation of the haplotypes circulating worldwide when implementing a vaccine, regardless of the geographic region of deployment since selective pressure plays an important role in structuring antigen diversity. © 2012 Chenet et al; licensee BioMed Central Ltd.
Volume
11
Language
English
OCDE Knowledge area
Inmunología
Parasitología
Parasitología
Subjects
Scopus EID
2-s2.0-84858023797
PubMed ID
Source
Malaria Journal
Sponsor(s)
Several authors of this manuscript are employees of the US Government. This work was prepared as part of their duties. Title 17 U.S.C. § 105 provides that ‘Copyright protection under this title is not available for any work of the United States Government.’ Title 17 U.S.C. § 101 defines US Government work as a work prepared by a military service member or employee of the US Government as part of that person’s official duties. The views expressed in this article are those of the authors only and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the US Government. This research was supported in part by the grant R01GM80586 from the National Institute of Health to AE.
Sources of information:
Directorio de Producción Científica
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