Title
Phenolic compounds obtained from stems of Couepia ulei with the potential to induce quinone reductase
Date Issued
29 February 2004
Access level
metadata only access
Resource Type
journal article
Author(s)
Dae S.J.
Eun J.P.
Kang Y.H.
Graham J.G.
Fong H.H.S.
Pezzuto J.M.
Kinghorn A.D.
Publisher(s)
Pharmaceutical Society of Korea
Abstract
Activity-guided fractionation of the EtOAc-soluble extract of the stems of Couepia ulei, using a bioassay based on the induction of quinone reductase (QR) in cultured Hepa 1c1c7 mouse hepatoma cells led to the isolation of two active compounds, a new natural product, erythro-2,3-bis(4-hydroxy-3-methoxyphenyl)-3- ethoxypropan-1-ol (1), and a known compound, evofolin-B (2), along with five inactive compounds all of known structure, viz., betulinic acid, oleanolic acid, pomolic acid, (±)-syringaresinol, and ursolic acid. These isolates were identified by analysis of physical and spectral data. Compounds 1 and 2 exhibited QR inducing activity, with observed CD (concentration required to double induction) values of 16.7 and 16.4 μM, respectively.
Start page
169
End page
172
Volume
27
Issue
2
Language
English
OCDE Knowledge area
Bioquímica, Biología molecular
Subjects
Scopus EID
2-s2.0-4444311317
PubMed ID
Source
Archives of Pharmacal Research
ISSN of the container
02536269
Sponsor(s)
We thank Dr. J. A. (Art) Anderson, Research Resources Center, University of Illinois at Chicago, and Dr. K. Fagerquist, Mass Spectrometry Facility, Department of Chemistry, University of Minnesota, Minneapolis, MN, for the mass spectral data. We are grateful to the Research Resources Center, UIC, for providing spectroscopic equipment, and to Dr. R. A. Kleps of the Research Resources Center, UIC, for facilitating the running of the 500 MHz NMR instrument. This research was supported by program project P01 CA48112, funded by the National Cancer Institute, NIH, Bethesda, MD.
Sources of information:
Directorio de Producción Científica
Scopus